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KMID : 0357920070410040266
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Korean Journal of Pathology
2007 Volume.41 No. 4 p.266 ~ p.270
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An Unusual Stroma-Rich Variant of Castleman’s Disease of the Hyaline-Vascular Type - A Case Report -The stroma-rich variant of Castleman’s disease of the hyaline-vascular type (CDHV) is a rare
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Jung Ji-Han
Lee Kyo-Young
Park Gyeong-Sin
Choi Hyun-Joo
Yoo Jin-Young
Kang Seok-Jin
Park Gyeong-Sin
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Abstract
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The stroma-rich variant of Castleman’s disease of the hyaline-vascular type (CDHV) is a rare entity that shows overgrowth of a variety of stromal cells in the widened interfollicular (IF) area. We report here on a case of a stroma-rich variant of CDHV in an 18-year-old man who presented with an asymptomatic solitary neck mass he’d had for 1 year. Histologically, an enlarged lymph node fulfilled the criteria of CDHV, along with vague nodularity of a widened IF area. The nodular lesion consisted of numerous vessels and a proliferation of spindle cells. Immunohistochemically, the spindle cells were positive for vimentin and smooth muscle actin, they were negative for desmin, CD21, CD34, CD68, ALK-1, and S-100 protein. This stromal lesion is typically hyperplastic and clinically benign, and it must be distinguished from neoplastic stromal proliferation associated with Castleman’s disease because of its potential for recurrence and metastasis.
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KEYWORD
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Castleman’s disease, Angiofollicular lymphoid hyperplasia, Stroma cells
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